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Central Lines, PICCs and Ports: What the Nurse Owns

Central Lines, PICCs and Ports: What the Nurse Owns

By Ruqia Qatawna, PhD, MSN, RN·8 min read·Updated 2026-10-06
The short answer

A newly inserted central line is not used until placement is confirmed on chest X-ray. Every dressing change and every access is a sterile procedure, and the hub is scrubbed before each entry. If air enters the line, clamp it, lie the client flat on their left side with the head down, give oxygen and call for help: that position traps air in the right atrium instead of letting it reach the lungs.

Central Line Care and CLABSI Prevention NCLEX Review

Central line care and CLABSI prevention: the bundle, the dressing, the flush and the complications.

From the Intensive NCLEX Course. See the course; the full video library is part of Pro and Ultimate.

Central-line questions reward two reflexes above all: a new line is not used until the X-ray confirms it, and air embolism is left side, head down. Around those sit a device table and a prevention bundle the exam draws from constantly.

The line types, and what differs

DeviceWhere it goesTypical useWhat the nurse should know
Non-tunnelled central catheterSubclavian, internal jugular or femoral; tip in the SVCDays to weeks; acute careHighest infection risk of the group. Femoral highest of all
PICCInserted in the arm (basilic or brachial); tip advanced to the SVCWeeks to monthsNo BP cuff, no venepuncture, no injections in that arm. Measure upper-arm circumference as a baseline for thrombosis
Tunnelled catheter (Hickman, Broviac)Tunnelled under the skin with an anchoring cuffMonths to yearsThe tunnel and cuff reduce infection risk
Implanted portReservoir under the skin on the chest wallLong term, intermittent — chemotherapyAccessed only with a non-coring (Huber) needle. Lowest infection risk; best body image

Central access allows what a peripheral line cannot: vesicants and chemotherapy, parenteral nutrition, high-concentration potassium, vasopressors, long courses of irritating antibiotics, and central venous pressure measurement. That is also why the complications are more serious.

Before first use, and at insertion

  • Chest X-ray to confirm tip position before the line is used — for a PICC as well as a chest line. Using an unconfirmed line is a tested error.
  • Insertion is done under maximal sterile barrier precautions: cap, mask, sterile gown and gloves, full drape, chlorhexidine prep allowed to dry.
  • The client is positioned head-down (Trendelenburg) for subclavian or jugular insertion and asked to perform a Valsalva as the catheter is inserted and removed — both raise venous pressure and keep air out.
  • Watch afterwards for pneumothorax: sudden dyspnoea, chest pain, decreased breath sounds on that side.
Protecting the sterile field: the one-inch outer border is contaminated, the field is kept dry, in view and above waist level
Central line insertion and dressing changes are sterile procedures: the outer inch is contaminated, anything below the waist or out of sight is contaminated, a wet field is contaminated.

Preventing CLABSI — the bundle

  • Hand hygiene before and after any contact with the line.
  • Scrub the hub with alcohol or chlorhexidine for the recommended time and let it dry — every access, every time. The single most quoted item in this topic.
  • Chlorhexidine skin antisepsis at dressing changes.
  • Sterile dressing changes — transparent dressings typically every 7 days, gauze every 2 days, and immediately whenever damp, loose or soiled.
  • Change administration sets per policy — more frequently for blood, blood products and lipid emulsions.
  • Review daily whether the line is still needed, and remove it as soon as it is not. Nothing prevents infection like not having a line.
  • Avoid the femoral site where a subclavian or jugular route is possible.

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The complications and what you do

ProblemWhat you seeWhat you do
Air embolismSudden dyspnoea, chest pain, hypotension, tachycardia, anxiety, sometimes a churning murmur; often at connection, disconnection or removalClamp the line. Position flat, left side, head down. Oxygen. Call for help. Left-lateral Trendelenburg traps air in the right atrium
Infection / CLABSIFever, chills — especially spiking when the line is flushed — redness, tenderness or drainage at the siteAssess, obtain cultures as ordered (often peripheral and line), notify. Do not simply keep using it
OcclusionSluggish or absent flow; unable to aspirateCheck for closed clamps and kinks, reposition, ask the client to raise the arm or turn the head. Never force a flush — a clot can be pushed into the circulation
ThrombosisArm, neck or facial swelling; visible distended veins on that sideStop using the line, notify. The baseline arm measurement is what makes this obvious early
Migration / dislodgementExternal length has changed; pain on infusion; swelling at the siteStop the infusion, secure the line, notify — the tip may no longer be central

Flushing: use a 10 mL or larger syringe barrel — smaller barrels generate high pressure and can rupture the catheter. Use a pulsatile push-pause technique and maintain positive pressure as you clamp so blood does not track back into the tip.

NCLEX tip: Two answers repeat almost verbatim. Any new central line that has not had its X-ray is not used, whatever the urgency in the stem. And air embolism is always left side, head down — an option offering right side, upright or high Fowler is the distractor.

Infiltration (pale, cool, swollen arm with tightness and a slowed infusion) compared with phlebitis (red, warm, tender, burning along the vein with a palpable cord)
At any IV site: pale, cool and swollen is infiltration; red, warm and tender along the vein is phlebitis. Stop the infusion and assess either way.

Educational use only: this article supports nursing review and does not replace clinical judgment, facility protocols, or instructions from an authorised prescriber.

Practice

5 NCLEX practice questions on this topic

The same questions, player and partial-credit scoring students use inside NCLEXPace: answer, submit, read the full rationale, then Next. Your score is waiting at the end. No account needed for these.

Question 1 of 5Score: 0%
Question 1 of 5Multiple Choice

Select the best answer.

While repositioning a client receiving parenteral nutrition, the nurse finds the central catheter tubing disconnected at the hub. The client is suddenly dyspneic and hypotensive and reports chest pain. After clamping the catheter, which action should the nurse take next?

Question 2 of 5Multiple Choice

A client with severe hyponatremia from SIADH is receiving 3% sodium chloride at 25 mL/hr through a central line. Baseline sodium was 116 mEq/L at 0600. At 1200, the repeat sodium is 125 mEq/L. Which action by the nurse is most appropriate?

Question 3 of 5Multiple Choice

Select the best answer.

A nurse notes a client's central venous pressure has been trending downward over the past several hours. What does the central venous pressure primarily reflect?

Question 4 of 5Multiple Choice

Select the best answer.

A 7-year-old is on day 10 of induction chemotherapy for acute lymphoblastic leukemia and has a tunneled central venous catheter.

FindingValue
Oral temperature38.5 C (101.3 F)

The morning complete blood count shows:

TestResult
WBC900/mm3
Segmented neutrophils8 percent
Bands2 percent

Which action should the nurse take first?

Question 5 of 5Bow-tie (NGN)

Complete the diagram by selecting one condition, two priority actions, and two parameters to monitor.

A client on day 6 of parenteral nutrition through a tunneled central catheter has a temperature of 38.9 C (102 F), shaking chills that began 1 hour after the infusion resumed, and redness with tenderness at the exit site. The white blood cell count is 18,000/mm3. Select the condition the nurse should suspect, the 2 priority actions, and the 2 parameters to monitor.

Click one option in each list to fill the diagram: 2 actions, 1 condition, 2 parameters. Click again to remove.
Actions to Take
,
,
Potential Condition
,
Parameters to Monitor
,
,
Actions to Take
Potential Conditions
Parameters to Monitor
0 answered · 0%
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Frequently asked questions

Common follow-up questions on Infection Control, Safety & Risk Reduction.

Why must a chest X-ray be done before using a new central line?

To confirm the catheter tip sits in the correct position, usually the lower superior vena cava, and to rule out pneumothorax from the insertion. Infusing through a malpositioned catheter can deliver vesicants or concentrated solutions into the wrong vessel or the pleural space.

What is the position for a suspected air embolism?

Clamp the catheter, then place the client flat on the left side with the head lowered (left-lateral Trendelenburg) so air is trapped in the right atrium rather than travelling to the pulmonary circulation. Give oxygen and call for help immediately.

What restrictions apply to the arm with a PICC line?

No blood pressure measurement, no venepuncture and no injections in that arm. Upper-arm circumference is measured at baseline so that swelling from thrombosis is recognised early.

Why is a 10 mL syringe used to flush a central line?

Smaller syringe barrels generate much higher pressure at the catheter tip and can rupture it. A 10 mL or larger barrel keeps pressure within a safe range, and a resistant line is never force-flushed because a clot can be dislodged into the circulation.

How is a port accessed?

With a non-coring Huber needle using sterile technique, after palpating the septum and preparing the skin with chlorhexidine. A standard hypodermic needle cores the septum and destroys the port.

What is the most effective way to prevent a central line infection?

Removing the line as soon as it is no longer needed. Beyond that, hand hygiene, scrubbing the hub before every access, chlorhexidine skin antisepsis, sterile dressing changes and daily review of necessity form the prevention bundle.

Sources and references

  1. Harding MM, Kwong J, Hagler D, Reinisch C. Lewis's Medical-Surgical Nursing: Assessment and Management of Clinical Problems. 12th ed. Elsevier; 2023; Chapter: Fluid, Electrolyte, and Acid-Base Imbalances.
  2. Buetti N, et al. Strategies to Prevent Central Line-Associated Bloodstream Infections in Acute-Care Hospitals: 2022 Update. Infection Control & Hospital Epidemiology. 2022;43(5):553-569.

Reviewed by the NCLEXPace team, October 2026.

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